Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

Lingling Zeng; Yang Yang; Yujuan Hu; Yu Sun; Zhengde Du; Zhen Xie; Tao Zhou; Weijia Kong

doi:10.1371/journal.pone.0088019

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Peer-reviewed

Research Article

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

Lingling Zeng ,

Contributed equally to this work with: Lingling Zeng, Yang Yang, Yujuan Hu

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Yang Yang ,

Contributed equally to this work with: Lingling Zeng, Yang Yang, Yujuan Hu

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Yujuan Hu ,

Contributed equally to this work with: Lingling Zeng, Yang Yang, Yujuan Hu

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Yu Sun,

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Zhengde Du,

Affiliation Department of Otorhinolaryngology, Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China
⨯
Zhen Xie,

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Tao Zhou,

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯
Weijia Kong

* E-mail: entwjkong@hust.edu.cn

Affiliation Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, P. R. China
⨯

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

Lingling Zeng,
Yang Yang,
Yujuan Hu,
Yu Sun,
Zhengde Du,
Zhen Xie,
Tao Zhou,
Weijia Kong

Published: February 4, 2014
https://doi.org/10.1371/journal.pone.0088019

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Auditory cortex
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Mitochondria
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Acetylation
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