A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP

Sergei M. Danilov; Michael S. Wade; Sylva L. Schwager; Ross G. Douglas; Andrew B. Nesterovitch; Isolda A. Popova; Kyle D. Hogarth; Nakul Bhardwaj; David E. Schwartz; Edward D. Sturrock; Joe G. N. Garcia

doi:10.1371/journal.pone.0088001

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Research Article

A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP

Sergei M. Danilov ,

* E-mail: danilov@uic.edu

Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Michael S. Wade,

Affiliation Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Sylva L. Schwager,

Affiliation Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa
⨯
Ross G. Douglas,

Affiliation Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa
⨯
Andrew B. Nesterovitch,

Affiliation Department of Dermatology, Rush University, Chicago, Illinois, United States of America
⨯
Isolda A. Popova,

Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
⨯
Kyle D. Hogarth,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Nakul Bhardwaj,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
David E. Schwartz,

Affiliation Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Edward D. Sturrock,

Affiliation Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa
⨯
Joe G. N. Garcia

Affiliation Department of Medicine, University of Arizona, Tucson, Arizona, United States of America
⨯

A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP

Sergei M. Danilov,
Michael S. Wade,
Sylva L. Schwager,
Ross G. Douglas,
Andrew B. Nesterovitch,
Isolda A. Popova,
Kyle D. Hogarth,
Nakul Bhardwaj,
David E. Schwartz,
Edward D. Sturrock

Published: February 4, 2014
https://doi.org/10.1371/journal.pone.0088001

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