Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease

Nelly M. Cruz; Yang Yuan; Barrett D. Leehy; Rinku Baid; Uday Kompella; Margaret M. DeAngelis; Pascal Escher; Neena B. Haider

doi:10.1371/journal.pone.0087942

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Peer-reviewed

Research Article

Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease

Nelly M. Cruz,

Affiliations Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
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Yang Yuan,

Affiliation Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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Barrett D. Leehy,

Affiliation Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
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Rinku Baid,

Affiliation Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
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Uday Kompella,

Affiliations Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Margaret M. DeAngelis,

Affiliation Ophthalmology and Visual Sciences, John A. Moran Eye Center, Center for Translational Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Pascal Escher,

Affiliation Institute for Research in Ophthalmology, Grand-Champsec Sion, Switzerland
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Neena B. Haider

* E-mail: neena_haider@meei.harvard.edu

Affiliations Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease

Nelly M. Cruz,
Yang Yuan,
Barrett D. Leehy,
Rinku Baid,
Uday Kompella,
Margaret M. DeAngelis,
Pascal Escher,
Neena B. Haider

Published: January 31, 2014
https://doi.org/10.1371/journal.pone.0087942

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14 Mar 2014
01:27 GMT
Most Recent

This is a very nice example of a functionally linked genetic background variation influencing disease phenotype. Posted by kpmitton on 14 Mar 2014 at 01:27 GMT

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