Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer

Kazuhiko Shien; Norimitsu Tanaka; Masami Watanabe; Junichi Soh; Masakiyo Sakaguchi; Keitaro Matsuo; Hiromasa Yamamoto; Masashi Furukawa; Hiroaki Asano; Kazunori Tsukuda; Yasutomo Nasu; Nam-Ho Huh; Shinichiro Miyoshi; Hiromi Kumon; Shinichi Toyooka

doi:10.1371/journal.pone.0087900

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Open Access

Peer-reviewed

Research Article

Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer

Kazuhiko Shien ,

Contributed equally to this work with: Kazuhiko Shien, Norimitsu Tanaka

Affiliations Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Norimitsu Tanaka ,

Contributed equally to this work with: Kazuhiko Shien, Norimitsu Tanaka

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Masami Watanabe,

Affiliations Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Center for Gene and Cell Therapy, Okayama University Hospital, Okayama, Japan, Innovation Center Okayama for Nanobio-Targeted Therapy (ICONT), Okayama University, Okayama, Japan
⨯
Junichi Soh,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Masakiyo Sakaguchi,

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Keitaro Matsuo,

Affiliation Department of Preventive Medicine, Kyusyu University Faculty of Medical Science, Fukuoka, Japan
⨯
Hiromasa Yamamoto,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Masashi Furukawa,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroaki Asano,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kazunori Tsukuda,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yasutomo Nasu,

Affiliation Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Nam-Ho Huh,

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shinichiro Miyoshi,

Affiliation Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiromi Kumon,

Affiliations Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Innovation Center Okayama for Nanobio-Targeted Therapy (ICONT), Okayama University, Okayama, Japan
⨯
Shinichi Toyooka

* E-mail: toyooka@md.okayama-u.ac.jp

Affiliations Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer

Kazuhiko Shien,
Norimitsu Tanaka,
Masami Watanabe,
Junichi Soh,
Masakiyo Sakaguchi,
Keitaro Matsuo,
Hiromasa Yamamoto,
Masashi Furukawa,
Hiroaki Asano,
Kazunori Tsukuda

Published: February 3, 2014
https://doi.org/10.1371/journal.pone.0087900

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Non-small cell lung cancer
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Cancer treatment
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Adenoviruses
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Lung and intrathoracic tumors
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