Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

• Christian Schmitt,

  Affiliation Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Dagmar Kail,

  Affiliation PharmBioTec GmbH, Saarbrücken, Germany

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• Marica Mariano,

  Affiliation Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Martin Empting,

  Affiliation Department of Drug Design and Optimization, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken, Germany

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• Nadja Weber,

  Affiliation Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Tamara Paul,

  Affiliation Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Rolf W. Hartmann,

  Affiliations Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Department of Drug Design and Optimization, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken, Germany

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• Matthias Engel

  * E-mail: ma.engel@mx.uni-saarland.de

  Affiliation Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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