The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation

Dana Berneman-Zeitouni; Kfir Molakandov; Marina Elgart; Eytan Mor; Alessia Fornoni; Miriam Ramírez Domínguez; Julie Kerr-Conte; Michael Ott; Irit Meivar-Levy; Sarah Ferber

doi:10.1371/journal.pone.0087812

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Open Access

Peer-reviewed

Research Article

The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation

Dana Berneman-Zeitouni,

Affiliations Sheba Regenerative Medicine, Stem cells and Tissue engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Kfir Molakandov,

Affiliations Sheba Regenerative Medicine, Stem cells and Tissue engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Marina Elgart,

Affiliations Sheba Regenerative Medicine, Stem cells and Tissue engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Eytan Mor,

Affiliation Rabin Medical Ctr., Beilinson Campus, Petah-Tiqva, Israel
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Alessia Fornoni,

Affiliation Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America
⨯
Miriam Ramírez Domínguez,

Affiliation Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America
⨯
Julie Kerr-Conte,

Affiliation University Lille Nord de France, Lille, France
⨯
Michael Ott,

Affiliation Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany; Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany
⨯
Irit Meivar-Levy,

Affiliation Sheba Regenerative Medicine, Stem cells and Tissue engineering Center, Sheba Medical Center, Tel-Hashomer, Israel
⨯
Sarah Ferber

* E-mail: sferber@sheba.health.gov.il

Affiliations Sheba Regenerative Medicine, Stem cells and Tissue engineering Center, Sheba Medical Center, Tel-Hashomer, Israel, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯

The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation

Dana Berneman-Zeitouni,
Kfir Molakandov,
Marina Elgart,
Eytan Mor,
Alessia Fornoni,
Miriam Ramírez Domínguez,
Julie Kerr-Conte,
Michael Ott,
Irit Meivar-Levy,
Sarah Ferber

Published: February 4, 2014
https://doi.org/10.1371/journal.pone.0087812

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Transdifferentiation
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Insulin
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Pancreas
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Gene expression
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Insulin secretion
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Somatostatin
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