E. coli Infection Modulates the Pharmacokinetics of Oral Enrofloxacin by Targeting P-Glycoprotein in Small Intestine and CYP450 3A in Liver and Kidney of Broilers

Open Access

Peer-reviewed

Research Article

Mengjie Guo,

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Yong Sun,

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Yu Zhang,

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Shamsuddin Bughio,

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Xiaohua Dai,

Affiliations Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China, College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, China
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Weilong Ren,

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Liping Wang

* E-mail: wlp71@163.com

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, PR China
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Escherichia coli infections
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Kidneys
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Pharmacokinetics
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Gastrointestinal infections
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Birds
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Small intestine
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Cell membranes
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Respiratory infections
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