Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia

Chunhua Jiang; Jianhua Cui; Fuyu Liu; Liang Gao; Yongjun Luo; Peng Li; Libin Guan; Yuqi Gao

doi:10.1371/journal.pone.0087775

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Peer-reviewed

Research Article

Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia

Chunhua Jiang,

Affiliations Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China, Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯
Jianhua Cui,

Affiliation Research Center of PLA for Prevention and Treatment of High Mountain Sickness, the 18th Hospital of PLA, Yecheng, Xinjiang, PR China
⨯
Fuyu Liu,

Affiliations Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯
Liang Gao,

Affiliation Research Center of PLA for Prevention and Treatment of High Mountain Sickness, the 18th Hospital of PLA, Yecheng, Xinjiang, PR China
⨯
Yongjun Luo,

Affiliations Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯
Peng Li,

Affiliations Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯
Libin Guan,

Affiliations Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China, Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯
Yuqi Gao

* E-mail: gaoy66@gmail.com

Affiliations Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China, Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, PR China, Key Laboratory of High Altitude Medicine, PLA, Chongqing, PR China
⨯

Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia

Chunhua Jiang,
Jianhua Cui,
Fuyu Liu,
Liang Gao,
Yongjun Luo,
Peng Li,
Libin Guan,
Yuqi Gao

Published: January 30, 2014
https://doi.org/10.1371/journal.pone.0087775

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