A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer

Tianping Chen; Huiping Wang; Zhiqiang Zhang; Qing Li; Kaili Yan; Qianshan Tao; Qianling Ye; Shudao Xiong; Yiping Wang; Zhimin Zhai

doi:10.1371/journal.pone.0087774

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Peer-reviewed

Research Article

A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer

Tianping Chen,

Affiliations Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China, Hematology Research Centre, Second Hospital of Anhui Medical University, Hefei, China
⨯
Huiping Wang,

Affiliations Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China, Hematology Research Centre, Second Hospital of Anhui Medical University, Hefei, China
⨯
Zhiqiang Zhang,

Affiliation Department of Urology, Second Hospital of Anhui Medical University, Hefei, China
⨯
Qing Li,

Affiliation Central Laboratory, Anhui Provincial Hospital, Hefei, China
⨯
Kaili Yan,

Affiliation Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China
⨯
Qianshan Tao,

Affiliation Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China
⨯
Qianling Ye,

Affiliations Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China, National Institutes of Health and WESTMEAD Transplants and Kidney Disease Research Centre, Sydney University, Sydney, Australia
⨯
Shudao Xiong,

Affiliations Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China, Hematology Research Centre, Second Hospital of Anhui Medical University, Hefei, China
⨯
Yiping Wang,

Affiliation National Institutes of Health and WESTMEAD Transplants and Kidney Disease Research Centre, Sydney University, Sydney, Australia
⨯
Zhimin Zhai

* E-mail: zzm889@163.com

Affiliations Department of Hematology, Second Hospital of Anhui Medical University, Hefei, China, Hematology Research Centre, Second Hospital of Anhui Medical University, Hefei, China
⨯

A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer

Tianping Chen,
Huiping Wang,
Zhiqiang Zhang,
Qing Li,
Kaili Yan,
Qianshan Tao,
Qianling Ye,
Shudao Xiong,
Yiping Wang,
Zhimin Zhai

Published: February 5, 2014
https://doi.org/10.1371/journal.pone.0087774

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Regulatory T cells
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Apoptosis
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Gene expression
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Bladder cancer
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