Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination

Open Access

Peer-reviewed

Research Article

Disruption of Myelin Leads to Ectopic Expression of K_V1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination

Bandita Bagchi,

Affiliation International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland
⨯
Ahmed Al-Sabi,

Affiliation International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland
⨯
Seshu Kaza,

Affiliation International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland
⨯
Dimitri Scholz,

Affiliation Conway Institute, University College Dublin, Belfield, Dublin, Ireland
⨯
Valerie B. O'Leary,

Affiliation International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland
⨯
J. Oliver Dolly ,

* E-mail: saak.ovsepian@gmail.com (SVO); oliver.dolly@dcu.ie (JOD)

Affiliation International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland
⨯
Saak V. Ovsepian

* E-mail: saak.ovsepian@gmail.com (SVO); oliver.dolly@dcu.ie (JOD)

Affiliations International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Republic of Ireland, Department of Biotechnology, Dublin City University, Glasnevin, Dublin, Republic of Ireland, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ludwig-Maximilians-Universität München, Zentrum für Neuropathologie, Feodor-Lynen-Str. 23, Munich, Germany
⨯

Axons
Is the Subject Area "Axons" applicable to this article?

Thanks for your feedback.
Multiple sclerosis
Is the Subject Area "Multiple sclerosis" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Optic nerve
Is the Subject Area "Optic nerve" applicable to this article?

Thanks for your feedback.
Action potentials
Is the Subject Area "Action potentials" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Potassium channels
Is the Subject Area "Potassium channels" applicable to this article?

Thanks for your feedback.
Sucrose
Is the Subject Area "Sucrose" applicable to this article?

Thanks for your feedback.