Promoter DNA Methylation of Farnesoid X Receptor and Pregnane X Receptor Modulates the Intrahepatic Cholestasis of Pregnancy Phenotype

• Romina Cabrerizo,

  Affiliation Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina

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• Gustavo O. Castaño,

  Affiliations Liver Unit, Medicine and Surgery Department, Hospital Abel Zubizarreta, Ciudad Autónoma de Buenos Aires, Argentina, Research Council in Health, Ciudad Autónoma de Buenos Aires, Argentina

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• Adriana L. Burgueño,

  Affiliation Department of Molecular Genetics and Biology of the Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina

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• Tomas Fernández Gianotti,

  Affiliation Department of Molecular Genetics and Biology of the Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina

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• María Mora Gonzalez Lopez Ledesma,

  Affiliation Department of Virology, School of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

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• Diego Flichman,

  Affiliation Department of Virology, School of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

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• Carlos J. Pirola ,

  * E-mail: pirola.carlos@lanari.fmed.uba.ar (CJP); ssookoian.silvia@lanari.fmed.uba.ar (SS)

  ¶These authors are joint senior authors on this work.

  Affiliation Department of Molecular Genetics and Biology of the Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina

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• Silvia Sookoian

  * E-mail: pirola.carlos@lanari.fmed.uba.ar (CJP); ssookoian.silvia@lanari.fmed.uba.ar (SS)

  ¶These authors are joint senior authors on this work.

  Affiliations Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina, Liver Unit, Medicine and Surgery Department, Hospital Abel Zubizarreta, Ciudad Autónoma de Buenos Aires, Argentina, Research Council in Health, Ciudad Autónoma de Buenos Aires, Argentina

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