IL-4 Suppresses the Responses to TLR7 and TLR9 Stimulation and Increases the Permissiveness to Retroviral Infection of Murine Conventional Dendritic Cells

Uma Sriram; Jun Xu; Robert W. Chain; Linda Varghese; Marita Chakhtoura; Heather L. Bennett; Philip W. Zoltick; Stefania Gallucci

doi:10.1371/journal.pone.0087668

Loading metrics

Open Access

Peer-reviewed

Research Article

IL-4 Suppresses the Responses to TLR7 and TLR9 Stimulation and Increases the Permissiveness to Retroviral Infection of Murine Conventional Dendritic Cells

Uma Sriram ,

* E-mail: sriram@temple.edu (US); gallucci@temple.edu (SG)

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jun Xu,

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Robert W. Chain,

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Linda Varghese,

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Marita Chakhtoura,

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Heather L. Bennett,

Affiliation Joseph Stokes, Jr. Research Institute, Division of Rheumatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Philip W. Zoltick,

Affiliation Department of Surgery, The Children's Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Stefania Gallucci

* E-mail: sriram@temple.edu (US); gallucci@temple.edu (SG)

Affiliation Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

IL-4 Suppresses the Responses to TLR7 and TLR9 Stimulation and Increases the Permissiveness to Retroviral Infection of Murine Conventional Dendritic Cells

Uma Sriram,
Jun Xu,
Robert W. Chain,
Linda Varghese,
Marita Chakhtoura,
Heather L. Bennett,
Philip W. Zoltick,
Stefania Gallucci

Published: January 29, 2014
https://doi.org/10.1371/journal.pone.0087668

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Immune receptor signaling
Is the Subject Area "Immune receptor signaling" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Interferons
Is the Subject Area "Interferons" applicable to this article?

Thanks for your feedback.
Viral transmission and infection
Is the Subject Area "Viral transmission and infection" applicable to this article?

Thanks for your feedback.
MHC class I genes
Is the Subject Area "MHC class I genes" applicable to this article?

Thanks for your feedback.