Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection

Ryuichi Uetake; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Yasuhiro Iesato; Takahiro Yoshizawa; Teruhide Koyama; Lei Yang; Yuichi Toriyama; Akihiro Yamauchi; Kyoko Igarashi; Megumu Tanaka; Takashige Kuwabara; Kiyoshi Mori; Motoko Yanagita; Masashi Mukoyama; Takayuki Shindo

doi:10.1371/journal.pone.0087667

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Open Access

Peer-reviewed

Research Article

Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection

Ryuichi Uetake,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Takayuki Sakurai,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Akiko Kamiyoshi,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Yuka Ichikawa-Shindo,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Hisaka Kawate,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Yasuhiro Iesato,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Takahiro Yoshizawa,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Teruhide Koyama,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Lei Yang,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Yuichi Toriyama,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Akihiro Yamauchi,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Kyoko Igarashi,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Megumu Tanaka,

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Takashige Kuwabara,

Affiliation Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Kiyoshi Mori,

Affiliations Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Motoko Yanagita,

Affiliation Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Masashi Mukoyama,

Affiliation Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
[ ... ],
Takayuki Shindo

* E-mail: tshindo@shinshu-u.ac.jp

Affiliation Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
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Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection

Ryuichi Uetake,
Takayuki Sakurai,
Akiko Kamiyoshi,
Yuka Ichikawa-Shindo,
Hisaka Kawate,
Yasuhiro Iesato,
Takahiro Yoshizawa,
Teruhide Koyama,
Lei Yang,
Yuichi Toriyama

Published: February 5, 2014
https://doi.org/10.1371/journal.pone.0087667

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Endoplasmic reticulum
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Cell death
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Renal system
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