Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

• Yukinori Okada,

  Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan, Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

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• Dorothee Diogo,

  Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Jeffrey D. Greenberg,

  Affiliation New York University Hospital for Joint Diseases, New York, New York, United States of America

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• Faten Mouassess,

  Affiliation Molecular Biology and Biotechnology Department, Human Genetics Division, Damascus, Syria

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• Walid A. L. Achkar,

  Affiliation Molecular Biology and Biotechnology Department, Human Genetics Division, Damascus, Syria

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• Robert S. Fulton,

  Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Joshua C. Denny,

  Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Namrata Gupta,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Daniel Mirel,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Stacy Gabriel,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Gang Li,

  Affiliation Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Joel M. Kremer,

  Affiliation Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, New York, United States of America

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• Dimitrios A. Pappas,

  Affiliation Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Robert J. Carroll,

  Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Anne E. Eyler,

  Affiliation Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Gosia Trynka,

  Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Eli A. Stahl,

  Affiliation The Department of Psychiatry at Mount Sinai School of Medicine, New York, New York, United States of America

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• Jing Cui,

  Affiliation Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Richa Saxena,

  Affiliation Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Marieke J. H. Coenen,

  Affiliation Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Henk-Jan Guchelaar,

  Affiliation Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands

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• Tom W. J. Huizinga,

  Affiliation Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands

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• Philippe Dieudé,

  Affiliations Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris, France, Université Paris 7-Diderot, Paris, France

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• Xavier Mariette,

  Affiliation Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre, France

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• Anne Barton,

  Affiliation Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

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• Helena Canhão,

  Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Santa Maria Hospital–CHLN, Lisbon, Portugal

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• João E. Fonseca,

  Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Santa Maria Hospital–CHLN, Lisbon, Portugal

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• Niek de Vries,

  Affiliation Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands

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• Paul P. Tak,

  Affiliations Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands, GlaxoSmithKline, Stevenage, United Kingdom

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• Larry W. Moreland,

  Affiliation Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• S. Louis Bridges Jr,

  Affiliation Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Corinne Miceli-Richard,

  Affiliation Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre, France

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• Hyon K. Choi,

  Affiliations Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Yoichiro Kamatani,

  Affiliations Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France

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• Pilar Galan,

  Affiliation Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny, France

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• Mark Lathrop,

  Affiliation McGill University and Génome Québec Innovation Centre, Montréal, Canada

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• Towfique Raj,

  Affiliations Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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• Philip L. De Jager,

  Affiliations Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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• Soumya Raychaudhuri,

  Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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• Jane Worthington,

  Affiliations Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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• Leonid Padyukov,

  Affiliation Rheumatology Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden

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• Lars Klareskog,

  Affiliation Rheumatology Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden

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• Katherine A. Siminovitch,

  Affiliations Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada, Toronto General Research Institute, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada

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• Peter K. Gregersen,

  Affiliation The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, United States of America

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• Elaine R. Mardis,

  Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Thurayya Arayssi,

  Affiliation Weill Cornell Medical College-Qatar, Education City, Doha, Qatar

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• Layla A. Kazkaz,

  Affiliations Tishreen Hospital, Damascus, Syria, Syrian Association for Rheumatology, Damascus, Syria

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•  [ ... ],
• Robert M. Plenge

  * E-mail: robert.plenge@merck.com

  Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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