A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877

Robert Bunet; Ramona Riclea; Luisa Laureti; Laurence Hôtel; Cédric Paris; Jean-Michel Girardet; Dieter Spiteller; Jeroen S. Dickschat; Pierre Leblond; Bertrand Aigle

doi:10.1371/journal.pone.0087607

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Research Article

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877

Robert Bunet,

Current address: †Université du Sud Toulon-Var, Equipe de Biologie Moléculaire Marine, Laboratoire Protée EA3819, La Garde 83957, France

Affiliations Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France, INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France
⨯
Ramona Riclea,

Affiliation Institute of Organic Chemistry, TU Braunschweig, Braunschweig, Germany
⨯
Luisa Laureti,

Current address: ‡Cancer Research Center of Marseille, Tolerance of lesions in DNA, CNRS UMR7258, Marseille F-13273, France

Affiliations Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France, INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France
⨯
Laurence Hôtel,

Affiliations Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France, INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France
⨯
Cédric Paris,

Affiliation Université de Lorraine, Laboratoire d’Ingénierie des Biomolécules, Ecole Nationale Supérieure d’Agronomie et des Industries Alimentaires, Vandœuvre-lès-Nancy, France
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Jean-Michel Girardet,

Affiliations Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (URAFPA), Vandœuvre-lès-Nancy Cedex, France, INRA,URAFPA, USC 340, Vandœuvre-lès-Nancy, France
⨯
Dieter Spiteller,

Affiliation Department of Biology, Chemical Ecology/Biological Chemistry, University of Konstanz, Konstanz, Germany
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Jeroen S. Dickschat,

Affiliation Institute of Organic Chemistry, TU Braunschweig, Braunschweig, Germany
⨯
Pierre Leblond,

Affiliations Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France, INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France
⨯
Bertrand Aigle

* E-mail: bertrand.aigle@univ-lorraine.fr

Affiliations Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France, INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy, France
⨯

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877

Robert Bunet,
Ramona Riclea,
Luisa Laureti,
Laurence Hôtel,
Cédric Paris,
Jean-Michel Girardet,
Dieter Spiteller,
Jeroen S. Dickschat,
Pierre Leblond,
Bertrand Aigle

Published: January 31, 2014
https://doi.org/10.1371/journal.pone.0087607

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