Inhibition of the K+ Channel KCa3.1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells

Rong-Guo Fu; Tao Zhang; Li Wang; Yan Du; Li-Ning Jia; Jing-Jing Hou; Gang-Lian Yao; Xiao-Dan Liu; Lei Zhang; Ling Chen; Bao-Song Gui; Rong-Liang Xue

doi:10.1371/journal.pone.0087410

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Peer-reviewed

Research Article

Inhibition of the K⁺ Channel K_Ca3.1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells

Rong-Guo Fu ,

Contributed equally to this work with: Rong-Guo Fu, Tao Zhang

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Tao Zhang ,

Contributed equally to this work with: Rong-Guo Fu, Tao Zhang

Affiliation School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Li Wang,

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Yan Du,

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Li-Ning Jia,

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Jing-Jing Hou,

Affiliation School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Gang-Lian Yao,

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Xiao-Dan Liu,

Affiliation Cadre's ward, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, P.R. China
⨯
Lei Zhang,

Affiliation Medical Laboratory, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, P.R. China
⨯
Ling Chen,

Affiliation Department of Oncology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Bao-Song Gui ,

* E-mail: xuerl2h@126.com (RLX); guibsdoctor@sina.com (BSG)

Affiliation Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯
Rong-Liang Xue

* E-mail: xuerl2h@126.com (RLX); guibsdoctor@sina.com (BSG)

Affiliation Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China
⨯

Inhibition of the K⁺ Channel K_Ca3.1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells

Rong-Guo Fu,
Tao Zhang,
Li Wang,
Yan Du,
Li-Ning Jia,
Jing-Jing Hou,
Gang-Lian Yao,
Xiao-Dan Liu,
Lei Zhang,
Ling Chen

Published: January 28, 2014
https://doi.org/10.1371/journal.pone.0087410

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