Increased Axonal Ribosome Numbers Is an Early Event in the Pathogenesis of Amyotrophic Lateral Sclerosis

Mark H. G. Verheijen; Marco Peviani; Rita Hendricusdottir; Erin M. Bell; Martin Lammens; August B. Smit; Caterina Bendotti; Jan van Minnen

doi:10.1371/journal.pone.0087255

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Peer-reviewed

Research Article

Increased Axonal Ribosome Numbers Is an Early Event in the Pathogenesis of Amyotrophic Lateral Sclerosis

Mark H. G. Verheijen,

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
⨯
Marco Peviani,

Current address: Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

Affiliation Laboratory of Molecular Neurobiology, Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Rita Hendricusdottir,

Current address: Institute of Psychiatry, King’s College London, London, United Kingdom

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
⨯
Erin M. Bell,

Affiliation Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
⨯
Martin Lammens,

Affiliation Department of Pathology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
⨯
August B. Smit,

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
⨯
Caterina Bendotti,

Affiliation Laboratory of Molecular Neurobiology, Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Jan van Minnen

* E-mail: jvanminn@ucalgary.ca

Affiliation Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
⨯

Increased Axonal Ribosome Numbers Is an Early Event in the Pathogenesis of Amyotrophic Lateral Sclerosis

Mark H. G. Verheijen,
Marco Peviani,
Rita Hendricusdottir,
Erin M. Bell,
Martin Lammens,
August B. Smit,
Caterina Bendotti,
Jan van Minnen

Published: January 30, 2014
https://doi.org/10.1371/journal.pone.0087255

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Ribosomes
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Axons
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Mouse models
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Axonal transport
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Schwann cells
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Amyotrophic lateral sclerosis
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Nerves
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Polyribosomes
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