Contribution of Baicalin on the Plasma Protein Binding Displacement and CYP3A Activity Inhibition to the Pharmacokinetic Changes of Nifedipine in Rats In Vivo and In Vitro

Open Access

Peer-reviewed

Research Article

Zhen-Yu Cheng ,

Contributed equally to this work with: Zhen-Yu Cheng, Xin Tian

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
⨯
Xin Tian ,

Contributed equally to this work with: Zhen-Yu Cheng, Xin Tian

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
⨯
Jie Gao,

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
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Hong-Meng Li,

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
⨯
Lin-Jing Jia,

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
⨯
Hai-Ling Qiao

* E-mail: qiaohl@zzu.edu.cn

Affiliation Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
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Pharmacokinetics
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Plasma proteins
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High performance liquid chromatography
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Blood plasma
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