Improving Predictions of Protein-Protein Interfaces by Combining Amino Acid-Specific Classifiers Based on Structural and Physicochemical Descriptors with Their Weighted Neighbor Averages

Fábio R. de Moraes; Izabella A. P. Neshich; Ivan Mazoni; Inácio H. Yano; José G. C. Pereira; José A. Salim; José G. Jardine; Goran Neshich

doi:10.1371/journal.pone.0087107

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Peer-reviewed

Research Article

Improving Predictions of Protein-Protein Interfaces by Combining Amino Acid-Specific Classifiers Based on Structural and Physicochemical Descriptors with Their Weighted Neighbor Averages

Fábio R. de Moraes,

Affiliations Biology Institute, University of Campinas, Campinas, São Paulo, Brazil, Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
Izabella A. P. Neshich,

Affiliations Biology Institute, University of Campinas, Campinas, São Paulo, Brazil, Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
Ivan Mazoni,

Affiliations Biology Institute, University of Campinas, Campinas, São Paulo, Brazil, Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
Inácio H. Yano,

Affiliation Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
José G. C. Pereira,

Affiliations Biology Institute, University of Campinas, Campinas, São Paulo, Brazil, Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
José A. Salim,

Affiliation School of Electrical and Computer Engineering, University of Campinas, Campinas, São Paulo, Brazil
⨯
José G. Jardine,

Affiliation Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯
Goran Neshich

* E-mail: Goran.Neshich@cnptia.embrapa.br

Affiliation Brazilian Agricultural Research Corporation (EMBRAPA), National Center for Agricultural Informatics, Campinas, São Paulo, Brazil
⨯

Improving Predictions of Protein-Protein Interfaces by Combining Amino Acid-Specific Classifiers Based on Structural and Physicochemical Descriptors with Their Weighted Neighbor Averages

Fábio R. de Moraes,
Izabella A. P. Neshich,
Ivan Mazoni,
Inácio H. Yano,
José G. C. Pereira,
José A. Salim,
José G. Jardine,
Goran Neshich

Published: January 28, 2014
https://doi.org/10.1371/journal.pone.0087107

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Hydrogen bonding
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Amino acid analysis
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Cysteine
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Protein structure
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Protein structure databases
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Protein structure prediction
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Linear discriminant analysis
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Protein-protein interactions
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