Mechanisms of Metabonomic for a Gateway Drug: Nicotine Priming Enhances Behavioral Response to Cocaine with Modification in Energy Metabolism and Neurotransmitter Level

Hongyu Li; Qian Bu; Bo Chen; Xue Shao; Zhengtao Hu; Pengchi Deng; Lei Lv; Yi Deng; Ruiming Zhu; Yan Li; Baolai Zhang; Jing Hou; Changman Du; Qian Zhao; Dengqi Fu; Yinglan Zhao; Xiaobo Cen

doi:10.1371/journal.pone.0087040

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Open Access

Peer-reviewed

Research Article

Mechanisms of Metabonomic for a Gateway Drug: Nicotine Priming Enhances Behavioral Response to Cocaine with Modification in Energy Metabolism and Neurotransmitter Level

Hongyu Li,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Qian Bu,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Bo Chen,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Xue Shao,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Zhengtao Hu,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Pengchi Deng,

Affiliation Analytical and Testing Center, Sichuan University, Chengdu, Sichuan, China
⨯
Lei Lv,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Yi Deng,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Ruiming Zhu,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Yan Li,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Baolai Zhang,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Jing Hou,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Changman Du,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Qian Zhao,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Dengqi Fu,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
Yinglan Zhao,

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
[ ... ],
Xiaobo Cen

* E-mail: xbcenalan@vip.sina.com

Affiliation National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, Sichuan University, Chengdu, Sichuan, China
⨯
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Mechanisms of Metabonomic for a Gateway Drug: Nicotine Priming Enhances Behavioral Response to Cocaine with Modification in Energy Metabolism and Neurotransmitter Level

Hongyu Li,
Qian Bu,
Bo Chen,
Xue Shao,
Zhengtao Hu,
Pengchi Deng,
Lei Lv,
Yi Deng,
Ruiming Zhu,
Yan Li

Published: January 28, 2014
https://doi.org/10.1371/journal.pone.0087040

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