The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation

• Esko Oksanen,

  Current address: European Spallation Source, Lund, Sweden

  Affiliation Institut de Biologie Structurale (IBS), Direction des Sciences du Vivant, Commissariat à l’Energie Atomique et aux Energies Alternatives, Grenoble, France, IBS, Centre National de la Recherche Scientifique, Grenoble, France, IBS, Université Grenoble Alpes, Grenoble, France

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• Matthew P. Blakeley,

  Affiliation Institut Laue-Langevin, Grenoble, France

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• Mohamed El-Hajji,

  Affiliation Sanofi, Montpellier, France

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• Ulf Ryde,

  Affiliation Department of Theoretical Chemistry Lund University, Lund, Sweden

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• Monika Budayova-Spano

  * E-mail: monika.spano@ibs.fr

  Affiliation Institut de Biologie Structurale (IBS), Direction des Sciences du Vivant, Commissariat à l’Energie Atomique et aux Energies Alternatives, Grenoble, France, IBS, Centre National de la Recherche Scientifique, Grenoble, France, IBS, Université Grenoble Alpes, Grenoble, France

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