Overexpression of IL-10 in C2D Macrophages Promotes a Macrophage Phenotypic Switch in Adipose Tissue Environments

Linglin Xie; Qiang Fu; Teresa M. Ortega; Lun Zhou; Dane Rasmussen; Jacy O’Keefe; Ke K. Zhang; Stephen K. Chapes

doi:10.1371/journal.pone.0086541

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Open Access

Peer-reviewed

Research Article

Overexpression of IL-10 in C2D Macrophages Promotes a Macrophage Phenotypic Switch in Adipose Tissue Environments

Linglin Xie ,

* E-mail: linglin.xie@med.und.edu

Affiliation Department of Basic Sciences, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Qiang Fu,

Affiliations Department of Basic Sciences, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America, Departments of Gerontology and Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Teresa M. Ortega,

Affiliation Division of Biology, Kansas State University, Manhattan, Kansas, United States of America
⨯
Lun Zhou,

Affiliations Department of Basic Sciences, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America, Departments of Gerontology and Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Dane Rasmussen,

Affiliation Department of Basic Sciences, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Jacy O’Keefe,

Affiliation Department of Basic Sciences, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Ke K. Zhang,

Affiliations Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America, North Dakota IDeA Network of Biomedical Research Excellence Bioinformatics Core, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Stephen K. Chapes

Affiliation Division of Biology, Kansas State University, Manhattan, Kansas, United States of America
⨯

Overexpression of IL-10 in C2D Macrophages Promotes a Macrophage Phenotypic Switch in Adipose Tissue Environments

Linglin Xie,
Qiang Fu,
Teresa M. Ortega,
Lun Zhou,
Dane Rasmussen,
Jacy O’Keefe,
Ke K. Zhang,
Stephen K. Chapes

Published: January 21, 2014
https://doi.org/10.1371/journal.pone.0086541

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Macrophages
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Adipose tissue
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Adipocytes
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Cytokines
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Secretion
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Inflammation
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Adoptive transfer
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Hyperexpression techniques
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