Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis

Satish K. Madala; Ramakrishna Edukulla; Mukta Phatak; Stephanie Schmidt; Cynthia Davidson; Thomas H. Acciani; Thomas R. Korfhagen; Mario Medvedovic; Timothy D. LeCras; Kimberly Wagner; William D. Hardie

doi:10.1371/journal.pone.0086536

Loading metrics

Open Access

Peer-reviewed

Research Article

Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis

Satish K. Madala,

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Ramakrishna Edukulla,

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Mukta Phatak,

Affiliation Laboratory for Statistical Genomics and Systems Biology, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Stephanie Schmidt,

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Cynthia Davidson,

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Thomas H. Acciani,

Affiliation Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Thomas R. Korfhagen,

Affiliation Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Mario Medvedovic,

Affiliation Laboratory for Statistical Genomics and Systems Biology, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Timothy D. LeCras,

Affiliation Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Kimberly Wagner,

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
William D. Hardie

* E-mail: william.hardie@cchmc.org

Affiliation Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯

Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis

Satish K. Madala,
Ramakrishna Edukulla,
Mukta Phatak,
Stephanie Schmidt,
Cynthia Davidson,
Thomas H. Acciani,
Thomas R. Korfhagen,
Mario Medvedovic,
Timothy D. LeCras,
Kimberly Wagner

Published: January 27, 2014
https://doi.org/10.1371/journal.pone.0086536

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Pulmonary fibrosis
Is the Subject Area "Pulmonary fibrosis" applicable to this article?

Thanks for your feedback.
MAPK signaling cascades
Is the Subject Area "MAPK signaling cascades" applicable to this article?

Thanks for your feedback.
Pleurae
Is the Subject Area "Pleurae" applicable to this article?

Thanks for your feedback.
Collagens
Is the Subject Area "Collagens" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.