Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation

Open Access

Peer-reviewed

Research Article

Laura Monturiol-Gross,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
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Marietta Flores-Díaz,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Maria Jose Pineda-Padilla,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
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Ana Cristina Castro-Castro,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
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Alberto Alape-Giron

* E-mail: alberto.alape@ucr.ac.cr

Affiliations Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica, Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica, Centro de investigación en estructuras microscópicas, Universidad de Costa Rica, San José, Costa Rica
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Cytotoxicity
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Toxins
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Clostridial myonecrosis
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Protein kinases
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Apoptosis
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Redox signaling
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Clostridium perfringens
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Stress signaling cascade
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