Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

Harish Chandra Pal; Samriti Sharma; Leah Ray Strickland; Santosh K. Katiyar; Mary E. Ballestas; Mohammad Athar; Craig A. Elmets; Farrukh Afaq

doi:10.1371/journal.pone.0086338

Loading metrics

Open Access

Peer-reviewed

Research Article

Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

Harish Chandra Pal,

Affiliation Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Samriti Sharma,

Affiliation Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Leah Ray Strickland,

Affiliation Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Santosh K. Katiyar,

Affiliations Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Mary E. Ballestas,

Affiliation Department of Pediatrics Infectious Disease, Children's of Alabama, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Mohammad Athar,

Affiliations Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Craig A. Elmets,

Affiliations Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Farrukh Afaq

* E-mail: fafaq@uab.edu

Affiliations Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

Harish Chandra Pal,
Samriti Sharma,
Leah Ray Strickland,
Santosh K. Katiyar,
Mary E. Ballestas,
Mohammad Athar,
Craig A. Elmets,
Farrukh Afaq

Published: January 23, 2014
https://doi.org/10.1371/journal.pone.0086338

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Melanoma cells
Is the Subject Area "Melanoma cells" applicable to this article?

Thanks for your feedback.
MAPK signaling cascades
Is the Subject Area "MAPK signaling cascades" applicable to this article?

Thanks for your feedback.
Melanoma
Is the Subject Area "Melanoma" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Cutaneous melanoma
Is the Subject Area "Cutaneous melanoma" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Vimentin
Is the Subject Area "Vimentin" applicable to this article?

Thanks for your feedback.