Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients

Chuan-Jiang Li; Liang Li; Li Lin; Hai-Xia Jiang; Ze-Yan Zhong; Wei-Mo Li; Yan-Jun Zhang; Ping Zheng; Xu-Hui Tan; Lin Zhou

doi:10.1371/journal.pone.0086206

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Open Access

Peer-reviewed

Research Article

Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients

Chuan-Jiang Li ,

Contributed equally to this work with: Chuan-Jiang Li, Liang Li

Affiliation Department of Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
⨯
Liang Li ,

Contributed equally to this work with: Chuan-Jiang Li, Liang Li

* E-mail: liliang@smu.edu.cn

Affiliation Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China
⨯
Li Lin,

Affiliation Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China
⨯
Hai-Xia Jiang,

Affiliation Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
⨯
Ze-Yan Zhong,

Affiliation Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China
⨯
Wei-Mo Li,

Affiliation Department of Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
⨯
Yan-Jun Zhang,

Affiliation College of Pharmacy, University of Cincinnati Academic Health Centre, Cincinnati, Ohio, United States of America
⨯
Ping Zheng,

Affiliation Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
⨯
Xu-Hui Tan,

Affiliation Department of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, PR China
⨯
Lin Zhou

Affiliation Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China
⨯

Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients

Chuan-Jiang Li,
Liang Li,
Li Lin,
Hai-Xia Jiang,
Ze-Yan Zhong,
Wei-Mo Li,
Yan-Jun Zhang,
Ping Zheng,
Xu-Hui Tan,
Lin Zhou

Published: January 21, 2014
https://doi.org/10.1371/journal.pone.0086206

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