From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract

Sandra Ebeling; Katrin Naumann; Simone Pollok; Tina Wardecki; Sabine Vidal-y-Sy; Juliana M. Nascimento; Melanie Boerries; Gudula Schmidt; Johanna M. Brandner; Irmgard Merfort

doi:10.1371/journal.pone.0086147

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Open Access

Peer-reviewed

Research Article

From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract

Sandra Ebeling,

Affiliation Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Freiburg, Germany
⨯
Katrin Naumann,

Affiliation Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Freiburg, Germany
⨯
Simone Pollok,

Affiliation Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
⨯
Tina Wardecki,

Affiliation Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Freiburg, Germany
⨯
Sabine Vidal-y-Sy,

Affiliation Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
⨯
Juliana M. Nascimento,

Affiliations Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany
⨯
Melanie Boerries,

Affiliations Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Gudula Schmidt,

Affiliation Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University Freiburg, Freiburg, Germany
⨯
Johanna M. Brandner,

Affiliation Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
⨯
Irmgard Merfort

* E-mail: Irmgard.Merfort@pharmazie.uni-freiburg.de

Affiliation Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Freiburg, Germany
⨯

From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract

Sandra Ebeling,
Katrin Naumann,
Simone Pollok,
Tina Wardecki,
Sabine Vidal-y-Sy,
Juliana M. Nascimento,
Melanie Boerries,
Gudula Schmidt,
Johanna M. Brandner,
Irmgard Merfort

Published: January 22, 2014
https://doi.org/10.1371/journal.pone.0086147

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