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Open Access
Peer-reviewed
Research Article
Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia
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Karolina A. P. Wijnands ,
* E-mail: n.wijnands@maastrichtuniversity.nl
Affiliations Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands
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Marten A. Hoeksema,
Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Dennis M. Meesters,
Affiliations Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands
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Nynke M. S. van den Akker,
Affiliations Department of Cardiology, Maastricht University Medical Centre, Maastricht, the Netherlands, CARIM Cardiovascular Research Institute of Maastricht, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Physiology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Daniel G. M. Molin,
Affiliations CARIM Cardiovascular Research Institute of Maastricht, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Physiology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Jacob J. Briedé,
Affiliations Department of Toxicogenomics, Maastricht University Medical Centre, Maastricht, the Netherlands, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Mitrajit Ghosh,
Affiliations CARIM Cardiovascular Research Institute of Maastricht, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Genetics & cell Biology, Section Molecular Cell Biology, Maastricht University Medical Centre, Maastricht, the Netherlands
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S. Eleonore Köhler,
Affiliations NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Anatomy & Embryology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Marc A. M. J. van Zandvoort,
Affiliations CARIM Cardiovascular Research Institute of Maastricht, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Genetics & cell Biology, Section Molecular Cell Biology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Menno P. J. de Winther,
Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Wim A. Buurman,
Affiliations Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands
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Wouter H. Lamers,
Affiliations NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands, Department of Anatomy & Embryology, Maastricht University Medical Centre, Maastricht, the Netherlands
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Martijn Poeze
Affiliations Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands
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Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia
- Karolina A. P. Wijnands,
- Marten A. Hoeksema,
- Dennis M. Meesters,
- Nynke M. S. van den Akker,
- Daniel G. M. Molin,
- Jacob J. Briedé,
- Mitrajit Ghosh,
- S. Eleonore Köhler,
- Marc A. M. J. van Zandvoort,
- Menno P. J. de Winther
- Published: January 21, 2014
- https://doi.org/10.1371/journal.pone.0086135