Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis

• Brittany B. Dennis,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada, Population Genomics Program, McMaster University, Hamilton, Ontario, Canada

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• Monica Bawor,

  Affiliations Population Genomics Program, McMaster University, Hamilton, Ontario, Canada, McMaster Integrative Neuroscience Discovery & Study (MiNDS) Program, McMaster University, Hamilton, Ontario, Canada

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• Lehana Thabane,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada, Population Genomics Program, McMaster University, Hamilton, Ontario, Canada, Departments of Pediatrics and Anesthesia, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada

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• Zahra Sohani,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Population Genomics Program, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada

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• Zainab Samaan

  * E-mail: samaanz@mcmaster.ca

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Population Genomics Program, McMaster University, Hamilton, Ontario, Canada, McMaster Integrative Neuroscience Discovery & Study (MiNDS) Program, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada

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