Release of Tensile Strain on Engineered Human Tendon Tissue Disturbs Cell Adhesions, Changes Matrix Architecture, and Induces an Inflammatory Phenotype

Monika L. Bayer; Peter Schjerling; Andreas Herchenhan; Cedric Zeltz; Katja M. Heinemeier; Lise Christensen; Michael Krogsgaard; Donald Gullberg; Michael Kjaer

doi:10.1371/journal.pone.0086078

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Open Access

Peer-reviewed

Research Article

Release of Tensile Strain on Engineered Human Tendon Tissue Disturbs Cell Adhesions, Changes Matrix Architecture, and Induces an Inflammatory Phenotype

Monika L. Bayer ,

* E-mail: Monika.Lucia.Bayer@regionh.dk

Affiliation Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Peter Schjerling,

Affiliation Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Andreas Herchenhan,

Affiliation Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Cedric Zeltz,

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway
⨯
Katja M. Heinemeier,

Affiliation Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Lise Christensen,

Affiliation Department of Pathology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
⨯
Michael Krogsgaard,

Affiliation Section for Sports Traumatology, Department of Orthopedic Surgery M, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
⨯
Donald Gullberg,

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway
⨯
Michael Kjaer

Affiliation Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Release of Tensile Strain on Engineered Human Tendon Tissue Disturbs Cell Adhesions, Changes Matrix Architecture, and Induces an Inflammatory Phenotype

Monika L. Bayer,
Peter Schjerling,
Andreas Herchenhan,
Cedric Zeltz,
Katja M. Heinemeier,
Lise Christensen,
Michael Krogsgaard,
Donald Gullberg,
Michael Kjaer

Published: January 21, 2014
https://doi.org/10.1371/journal.pone.0086078

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Tendons
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Collagens
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Integrins
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Extracellular matrix
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Gene expression
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Mechanical tension
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Cell differentiation
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