A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis

Yichi Zhang; Lu Lu; Jianping Jia; Longfei Jia; Changiz Geula; Jinjing Pei; Zhiqing Xu; Wei Qin; Ruiqin Liu; Dan Li; Na Pan

doi:10.1371/journal.pone.0085885

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Open Access

Peer-reviewed

Research Article

A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis

Yichi Zhang ,

Contributed equally to this work with: Yichi Zhang, Lu Lu

Affiliation Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
⨯
Lu Lu ,

Contributed equally to this work with: Yichi Zhang, Lu Lu

Affiliation Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
⨯
Jianping Jia ,

* E-mail: jiajp@vip.126.com

Affiliations Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China, Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China
⨯
Longfei Jia,

Affiliation Department of Neurology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China
⨯
Changiz Geula,

Affiliation Laboratory for Cognitive and Molecular Morphometry, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Jinjing Pei,

Affiliation Department of Neurobiology, Karolinska Institutet, Stockholm, Sweden
⨯
Zhiqing Xu,

Affiliation Department of Neurobiology, Capital Medical University, Beijing, China
⨯
Wei Qin,

Affiliations Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China, Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China
⨯
Ruiqin Liu,

Affiliations Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China, Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China
⨯
Dan Li,

Affiliations Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China, Key Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China
⨯
Na Pan

Affiliation Department of Neurobiology, Capital Medical University, Beijing, China
⨯

A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis

Yichi Zhang,
Lu Lu,
Jianping Jia,
Longfei Jia,
Changiz Geula,
Jinjing Pei,
Zhiqing Xu,
Wei Qin,
Ruiqin Liu,
Dan Li

Published: January 21, 2014
https://doi.org/10.1371/journal.pone.0085885

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