Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons

Yulin Zhang; Fengli Song; Ziyun Gao; Wei Ding; Luxin Qiao; Sufang Yang; Xi Chen; Ronghua Jin; Dexi Chen

doi:10.1371/journal.pone.0085637

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Open Access

Peer-reviewed

Research Article

Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons

Yulin Zhang ,

Contributed equally to this work with: Yulin Zhang, Fengli Song, Ziyun Gao

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Fengli Song ,

Contributed equally to this work with: Yulin Zhang, Fengli Song, Ziyun Gao

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Ziyun Gao ,

Contributed equally to this work with: Yulin Zhang, Fengli Song, Ziyun Gao

Affiliation Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
⨯
Wei Ding,

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Luxin Qiao,

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Sufang Yang,

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Xi Chen ,

* E-mail: dexi0963@yahoo.com (DC); jin_eagle@sina.com (RJ); jsxycx@sina.com (XC)

Affiliation Department of Otolaryngology, The First Affiliated Hospital Of Nanjing Medical University, Nanjing, China
⨯
Ronghua Jin ,

* E-mail: dexi0963@yahoo.com (DC); jin_eagle@sina.com (RJ); jsxycx@sina.com (XC)

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯
Dexi Chen

* E-mail: dexi0963@yahoo.com (DC); jin_eagle@sina.com (RJ); jsxycx@sina.com (XC)

Affiliation Department of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
⨯

Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons

Yulin Zhang,
Fengli Song,
Ziyun Gao,
Wei Ding,
Luxin Qiao,
Sufang Yang,
Xi Chen,
Ronghua Jin,
Dexi Chen

Published: January 20, 2014
https://doi.org/10.1371/journal.pone.0085637

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Mitochondrial DNA
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Neurons
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Nucleosides
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Mitochondria
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Toxicity
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Central nervous system
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Polymerase chain reaction
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Highly-active antiretroviral therapy
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