Angiopoietin-Like Protein 2 Induced by Mechanical Stress Accelerates Degeneration and Hypertrophy of the Ligamentum Flavum in Lumbar Spinal Canal Stenosis

Takayuki Nakamura; Tatsuya Okada; Motoyoshi Endo; Tsuyoshi Kadomatsu; Takuya Taniwaki; Akira Sei; Haruki Odagiri; Tetsuro Masuda; Toru Fujimoto; Takafumi Nakamura; Yuichi Oike; Hiroshi Mizuta

doi:10.1371/journal.pone.0085542

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Peer-reviewed

Research Article

Angiopoietin-Like Protein 2 Induced by Mechanical Stress Accelerates Degeneration and Hypertrophy of the Ligamentum Flavum in Lumbar Spinal Canal Stenosis

Takayuki Nakamura,

Affiliations Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan, Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Tatsuya Okada ,

* E-mail: tatsuya-okada@fc.kuh.kumamoto-u.ac.jp

Affiliation Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Motoyoshi Endo,

Affiliation Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Tsuyoshi Kadomatsu,

Affiliation Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Takuya Taniwaki,

Affiliation Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Akira Sei,

Affiliation Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Haruki Odagiri,

Affiliations Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan, Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Tetsuro Masuda,

Affiliations Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan, Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Toru Fujimoto,

Affiliation Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯
Takafumi Nakamura,

Affiliation Nakamura Orthopaedic Clinic, Ikeda-machi, Kita-ku, Kumamoto, Japan
⨯
Yuichi Oike,

Affiliations Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan, CREST, Japan Science and Technology Agency, Honcho, Kawaguchi, Saitama, Japan
⨯
Hiroshi Mizuta

Affiliation Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
⨯

Angiopoietin-Like Protein 2 Induced by Mechanical Stress Accelerates Degeneration and Hypertrophy of the Ligamentum Flavum in Lumbar Spinal Canal Stenosis

Takayuki Nakamura,
Tatsuya Okada,
Motoyoshi Endo,
Tsuyoshi Kadomatsu,
Takuya Taniwaki,
Akira Sei,
Haruki Odagiri,
Tetsuro Masuda,
Toru Fujimoto,
Takafumi Nakamura

Published: January 17, 2014
https://doi.org/10.1371/journal.pone.0085542

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