A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21WAF1/Cip1 Induction and Mitochondrial Dysfunction

África Millán-Uclés; Blanca Díaz-Castro; Paula García-Flores; Alicia Báez; José Antonio Pérez-Simón; José López-Barneo; José I. Piruat

doi:10.1371/journal.pone.0085528

Loading metrics

Open Access

Peer-reviewed

Research Article

A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21^WAF1/Cip1 Induction and Mitochondrial Dysfunction

África Millán-Uclés,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Departamento de Hematología. Hospital Universitario Virgen del Rocío. Seville, Spain
⨯
Blanca Díaz-Castro,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Paula García-Flores,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Alicia Báez,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Departamento de Hematología. Hospital Universitario Virgen del Rocío. Seville, Spain
⨯
José Antonio Pérez-Simón,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Departamento de Hematología. Hospital Universitario Virgen del Rocío. Seville, Spain
⨯
José López-Barneo,

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
José I. Piruat

* E-mail: jpiruat-ibis@us.es

Affiliations Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Seville, Spain, Departamento de Hematología. Hospital Universitario Virgen del Rocío. Seville, Spain
⨯

A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21^WAF1/Cip1 Induction and Mitochondrial Dysfunction

África Millán-Uclés,
Blanca Díaz-Castro,
Paula García-Flores,
Alicia Báez,
José Antonio Pérez-Simón,
José López-Barneo,
José I. Piruat

Published: January 20, 2014
https://doi.org/10.1371/journal.pone.0085528

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Tumor suppressor genes
Is the Subject Area "Tumor suppressor genes" applicable to this article?

Thanks for your feedback.