Cerebral Ischemia Is Exacerbated by Extracellular Nicotinamide Phosphoribosyltransferase via a Non-Enzymatic Mechanism

• Bing Zhao ,

  Contributed equally to this work with: Bing Zhao, Meng Zhang

  Affiliations Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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• Meng Zhang ,

  Contributed equally to this work with: Bing Zhao, Meng Zhang

  Affiliation Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China

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• Xue Han,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Xia-Yan Zhang,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Qiong Xing,

  Affiliation State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

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• Xu Dong,

  Affiliation State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

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• Qiao-Juan Shi,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Peng Huang,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Yun-Bi Lu,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Er-Qing Wei,

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Qiang Xia,

  Affiliation Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China

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• Wei-Ping Zhang ,

  * E-mail: weiping601@zju.edu.cn

  Affiliation Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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• Chun Tang

  Affiliation State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

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