Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)

• Xiang Xu ,

  Contributed equally to this work with: Xiang Xu, Yuan Cai

  Affiliation Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Yuan Cai ,

  Contributed equally to this work with: Xiang Xu, Yuan Cai

  Affiliations Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China

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• Ying Wei,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Fernando Donate,

  Affiliation Agensys, St. Santa Monica, California, United States of America

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• Jose Juarez,

  Affiliation GNF, San Diego, California, United States of America

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• Graham Parry,

  Affiliation Attenuon, San Diego, California, United States of America

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• Liqing Chen,

  Affiliation Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, United States of America

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• Edward J. Meehan,

  Affiliation Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, United States of America

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• Richard W. Ahn,

  Affiliation Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America

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• Andrey Ugolkov,

  Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

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• Oleksii Dubrovskyi,

  Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

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• Thomas V. O'Halloran,

  Affiliations Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America, Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America

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• Mingdong Huang ,

  * E-mail: mhuang1@bidmc.harvard.edu (MH); a-mazar@northwestern.edu (APM)

  Affiliation Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Andrew P. Mazar

  * E-mail: mhuang1@bidmc.harvard.edu (MH); a-mazar@northwestern.edu (APM)

  Affiliations Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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