The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death Pathway

• Dongmei Ji ,

  Contributed equally to this work with: Dongmei Ji, Zhe Zhang

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Zhe Zhang ,

  Contributed equally to this work with: Dongmei Ji, Zhe Zhang

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Lei Cheng,

  Affiliation Department of Interventional Radiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu, China

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• Jinjia Chang,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Shanshan Wang,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Biqiang Zheng,

  Affiliation Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Rongliang Zheng,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Zuojun Sun,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Chenchen Wang,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Zhiqing Zhang,

  Affiliation Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China

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• Rujiao Liu,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Xiaowei Zhang,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Xin Liu,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Xiaofeng Wang,

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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• Jin Li

  * E-mail: fudanlijin@163.com

  Affiliation Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

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