Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy

Shaday Michan; Aimee M. Juan; Christian G. Hurst; Zhenghao Cui; Lucy P. Evans; Colman J. Hatton; Dorothy T. Pei; Meihua Ju; David A. Sinclair; Lois E. H. Smith; Jing Chen

doi:10.1371/journal.pone.0085031

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Peer-reviewed

Research Article

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy

Shaday Michan,

Affiliation Instituto Nacional de Geriatría, Institutos Nacionales de Salud, México
⨯
Aimee M. Juan,

Affiliations Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Christian G. Hurst,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Zhenghao Cui,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Lucy P. Evans,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Colman J. Hatton,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dorothy T. Pei,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Meihua Ju,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David A. Sinclair,

Affiliations Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pharmacology, The University of New South Wales, Kensington, Australia
⨯
Lois E. H. Smith,

Affiliation Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jing Chen

* E-mail: jing.chen@childrens.harvard.edu

Affiliations Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy

Shaday Michan,
Aimee M. Juan,
Christian G. Hurst,
Zhenghao Cui,
Lucy P. Evans,
Colman J. Hatton,
Dorothy T. Pei,
Meihua Ju,
David A. Sinclair,
Lois E. H. Smith

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0085031

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Oxygen-induced retinopathy
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Retina
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Mouse models
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Neurons
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Retinal degeneration
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