Ubiquitin-Specific Protease 5 Is Required for the Efficient Repair of DNA Double-Strand Breaks

Satoshi Nakajima; Li Lan; Leizhen Wei; Ching-Lung Hsieh; Vesna Rapić-Otrin; Akira Yasui; Arthur S. Levine

doi:10.1371/journal.pone.0084899

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Open Access

Peer-reviewed

Research Article

Ubiquitin-Specific Protease 5 Is Required for the Efficient Repair of DNA Double-Strand Breaks

Satoshi Nakajima ,

* E-mail: san48@pitt.edu (SN); lil64@pitt.edu (LL)

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Li Lan ,

* E-mail: san48@pitt.edu (SN); lil64@pitt.edu (LL)

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Leizhen Wei,

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Ching-Lung Hsieh,

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Vesna Rapić-Otrin,

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Akira Yasui,

Affiliation Division of the Dynamic Proteome, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
⨯
Arthur S. Levine

Affiliation Department of Microbiology and Molecular Genetics and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Ubiquitin-Specific Protease 5 Is Required for the Efficient Repair of DNA Double-Strand Breaks

Satoshi Nakajima,
Li Lan,
Leizhen Wei,
Ching-Lung Hsieh,
Vesna Rapić-Otrin,
Akira Yasui,
Arthur S. Levine

Published: January 14, 2014
https://doi.org/10.1371/journal.pone.0084899

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DNA repair
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DNA damage
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Small interfering RNA
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Lasers
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Non-homologous end joining
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Ubiquitination
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Transfection
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Ligases
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