Pyruvate Protects Pathogenic Spirochetes from H2O2 Killing

Bryan Troxell; Jun-Jie Zhang; Travis J. Bourret; Melody Yue Zeng; Janice Blum; Frank Gherardini; Hosni M. Hassan; X. Frank Yang

doi:10.1371/journal.pone.0084625

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Open Access

Peer-reviewed

Research Article

Pyruvate Protects Pathogenic Spirochetes from H₂O₂ Killing

Bryan Troxell,

Current address: Prestage Department of Poultry Science, North Carolina State University, Raleigh, North Carolina, United States of America

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Jun-Jie Zhang,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Travis J. Bourret,

Affiliation Department of Biology, University of Nebraska Kearney, Nebraska, United States of America
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Melody Yue Zeng,

Current address: Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Janice Blum,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Frank Gherardini,

Affiliation Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, United States of America
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Hosni M. Hassan ,

* E-mail: xfyang@iupui.edu (XFY); hmhassan@ncsu.edu (HMH)

Current address: Prestage Department of Poultry Science, North Carolina State University, Raleigh, North Carolina, United States of America

Affiliation Department of Microbiology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
X. Frank Yang

* E-mail: xfyang@iupui.edu (XFY); hmhassan@ncsu.edu (HMH)

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

Pyruvate Protects Pathogenic Spirochetes from H₂O₂ Killing

Bryan Troxell,
Jun-Jie Zhang,
Travis J. Bourret,
Melody Yue Zeng,
Janice Blum,
Frank Gherardini,
Hosni M. Hassan,
X. Frank Yang

Published: January 2, 2014
https://doi.org/10.1371/journal.pone.0084625

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Pyruvate
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Borrelia burgdorferi
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Neutrophils
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Leptospira interrogans
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Spirochetes
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DNA repair
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