Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser262 and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

Open Access

Peer-reviewed

Research Article

Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser²⁶² and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

Hamid Y. Qureshi ,

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
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Dong Han ,

Contributed equally to this work with: Hamid Y. Qureshi, Dong Han

Affiliation Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
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Ryen MacDonald,

Affiliations Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
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Hemant K. Paudel

* E-mail: hemant.paudel@mcgill.ca

Affiliations Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
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Phosphorylation
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Neurons
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Microtubules
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Alzheimer's disease
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Hyperexpression techniques
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Synapses
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Neuronal differentiation
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Hippocampus
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