Deriving a Mutation Index of Carcinogenicity Using Protein Structure and Protein Interfaces

Open Access

Peer-reviewed

Research Article

Octavio Espinosa ,

Contributed equally to this work with: Octavio Espinosa, Konstantinos Mitsopoulos

Affiliation Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
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Konstantinos Mitsopoulos ,

Contributed equally to this work with: Octavio Espinosa, Konstantinos Mitsopoulos

Affiliation Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
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Jarle Hakas,

Affiliation Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
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Frances Pearl,

Affiliations UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom, Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton, United Kingdom
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Marketa Zvelebil

* E-mail: Marketa.Zvelebil@icr.ac.uk

Affiliation Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
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Substitution mutation
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Cancers and neoplasms
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Mutation databases
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Protein structure
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Amino acid substitution
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Cancer genomics
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Missense mutation
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Mutation detection
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