A Chimeric HS4-SAR Insulator (IS2) That Prevents Silencing and Enhances Expression of Lentiviral Vectors in Pluripotent Stem Cells

Open Access

Peer-reviewed

Research Article

Karim Benabdellah ,

Contributed equally to this work with: Karim Benabdellah, Francisco Martín

* E-mail: francisco.martin@genyo.es (FM); Karim.benabdel@genyo.es (KB)

Affiliation Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain
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Alejandra Gutierrez-Guerrero,

Affiliation Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain
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Marién Cobo,

Affiliation Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain
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Pilar Muñoz,

Affiliation Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain
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Francisco Martín

Contributed equally to this work with: Karim Benabdellah, Francisco Martín

* E-mail: francisco.martin@genyo.es (FM); Karim.benabdel@genyo.es (KB)

Affiliation Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain
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Insulators
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Silencer elements
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DNA methylation
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Cell differentiation
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Enhancer elements
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Plasmid construction
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Polymerase chain reaction
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Stem cells
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