Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

Jong-Kuen Lee; Sae-Ra Park; Bong-Kwang Jung; Yoon-Kyung Jeon; Yeong-Shin Lee; Min-Kyoung Kim; Yong-Goo Kim; Ji-Young Jang; Chul-Woo Kim

doi:10.1371/journal.pone.0084256

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Peer-reviewed

Research Article

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

Jong-Kuen Lee,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Sae-Ra Park,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Bong-Kwang Jung,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Yoon-Kyung Jeon,

Affiliations Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea, Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
⨯
Yeong-Shin Lee,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Min-Kyoung Kim,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Yong-Goo Kim,

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Ji-Young Jang ,

* E-mail: jjy93@daum.net (JYJ); cwkim@snu.ac.kr (CWK)

Affiliation Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
⨯
Chul-Woo Kim

* E-mail: jjy93@daum.net (JYJ); cwkim@snu.ac.kr (CWK)

Affiliations Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea, Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
⨯

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

Jong-Kuen Lee,
Sae-Ra Park,
Bong-Kwang Jung,
Yoon-Kyung Jeon,
Yeong-Shin Lee,
Min-Kyoung Kim,
Yong-Goo Kim,
Ji-Young Jang,
Chul-Woo Kim

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0084256

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Exosomes
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MicroRNAs
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Cancers and neoplasms
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Breast cancer
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Mesenchymal stem cells
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Angiogenesis
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Tumor angiogenesis
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Hepatocellular carcinoma
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