Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma

Louise V. Wain; Linda Odenthal-Hesse; Razan Abujaber; Ian Sayers; Caroline Beardsmore; Erol A. Gaillard; Sally Chappell; Cristian M. Dogaru; Tricia McKeever; Tamar Guetta-Baranes; Noor Kalsheker; Claudia E. Kuehni; Ian P. Hall; Martin D. Tobin; Edward J. Hollox

doi:10.1371/journal.pone.0084192

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Open Access

Peer-reviewed

Research Article

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma

Louise V. Wain ,

* E-mail: louisewain@le.ac.uk

Affiliation Department of Health Sciences, University of Leicester, Leicester, United Kingdom
⨯
Linda Odenthal-Hesse,

Affiliation Department of Genetics, University of Leicester, Leicester, United Kingdom
⨯
Razan Abujaber,

Affiliation Department of Genetics, University of Leicester, Leicester, United Kingdom
⨯
Ian Sayers,

Affiliation Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom
⨯
Caroline Beardsmore,

Affiliations Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom, Institute for Lung Health, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
⨯
Erol A. Gaillard,

Affiliations Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom, Institute for Lung Health, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
⨯
Sally Chappell,

Affiliation School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Cristian M. Dogaru,

Affiliation Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
⨯
Tricia McKeever,

Affiliation School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Tamar Guetta-Baranes,

Affiliation School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Noor Kalsheker,

Affiliation School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
⨯
Claudia E. Kuehni,

Affiliation Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
⨯
Ian P. Hall,

Affiliation Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom
⨯
Martin D. Tobin,

Affiliations Department of Health Sciences, University of Leicester, Leicester, United Kingdom, Department of Genetics, University of Leicester, Leicester, United Kingdom, Institute for Lung Health, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
⨯
Edward J. Hollox

Affiliation Department of Genetics, University of Leicester, Leicester, United Kingdom
⨯

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma

Louise V. Wain,
Linda Odenthal-Hesse,
Razan Abujaber,
Ian Sayers,
Caroline Beardsmore,
Erol A. Gaillard,
Sally Chappell,
Cristian M. Dogaru,
Tricia McKeever,
Tamar Guetta-Baranes

Published: January 3, 2014
https://doi.org/10.1371/journal.pone.0084192

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Chronic obstructive pulmonary disease
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Pulmonary function
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Copy number variation
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Single nucleotide polymorphisms
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