B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

Katherine J. Nicholas; Emily K. Zern; Louise Barnett; Rita M. Smith; Shelly L. Lorey; Courtney A. Copeland; Shanmugalakshmi Sadagopal; Spyros A. Kalams

doi:10.1371/journal.pone.0084185

Loading metrics

Open Access

Peer-reviewed

Research Article

B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

Katherine J. Nicholas ,

Contributed equally to this work with: Katherine J. Nicholas, Emily K. Zern

Affiliation Department of Pathology, Microbiology and Immunology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Emily K. Zern ,

Contributed equally to this work with: Katherine J. Nicholas, Emily K. Zern

Affiliation Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Louise Barnett,

Affiliation Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Rita M. Smith,

Affiliation Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Shelly L. Lorey,

Current address: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Affiliation Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Courtney A. Copeland,

Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Shanmugalakshmi Sadagopal,

Current address: Yerkes Primate Research Center, Emory University, Atlanta, Georgia, United States of America

Affiliation Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Spyros A. Kalams

* E-mail: s.kalams@vanderbilt.edu

Affiliations Department of Pathology, Microbiology and Immunology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯

B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

Katherine J. Nicholas,
Emily K. Zern,
Louise Barnett,
Rita M. Smith,
Shelly L. Lorey,
Courtney A. Copeland,
Shanmugalakshmi Sadagopal,
Spyros A. Kalams

Published: December 16, 2013
https://doi.org/10.1371/journal.pone.0084185

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
HIV
Is the Subject Area "HIV" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Viral load
Is the Subject Area "Viral load" applicable to this article?

Thanks for your feedback.
Viremia
Is the Subject Area "Viremia" applicable to this article?

Thanks for your feedback.
HIV infections
Is the Subject Area "HIV infections" applicable to this article?

Thanks for your feedback.