Systemic Inflammation Decreases Pain Threshold in Humans In Vivo

Moniek de Goeij; Lucas T. van Eijk; Pascal Vanelderen; Oliver H. Wilder-Smith; Kris C. Vissers; Johannes G. van der Hoeven; Matthijs Kox; Gert Jan Scheffer; Peter Pickkers

doi:10.1371/journal.pone.0084159

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Open Access

Peer-reviewed

Research Article

Systemic Inflammation Decreases Pain Threshold in Humans In Vivo

Moniek de Goeij,

Affiliation Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands
⨯
Lucas T. van Eijk,

Affiliations Department of Intensive Care Medicine, RUNMC, Nijmegen, The Netherlands, Nijmegen Institute for Infection, inflammation and Immunity. RUNMC, Nijmegen, The Netherlands
⨯
Pascal Vanelderen,

Affiliation Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands
⨯
Oliver H. Wilder-Smith,

Affiliation Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands
⨯
Kris C. Vissers,

Affiliation Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands
⨯
Johannes G. van der Hoeven,

Affiliations Department of Intensive Care Medicine, RUNMC, Nijmegen, The Netherlands, Nijmegen Institute for Infection, inflammation and Immunity. RUNMC, Nijmegen, The Netherlands
⨯
Matthijs Kox,

Affiliations Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands, Department of Intensive Care Medicine, RUNMC, Nijmegen, The Netherlands, Nijmegen Institute for Infection, inflammation and Immunity. RUNMC, Nijmegen, The Netherlands
⨯
Gert Jan Scheffer,

Affiliation Department of Anesthesiology, Pain and Palliative Medicine. RUNMC, Nijmegen, The Netherlands
⨯
Peter Pickkers

* E-mail: p.pickkers@ic.umcn.nl

Affiliations Department of Intensive Care Medicine, RUNMC, Nijmegen, The Netherlands, Nijmegen Institute for Infection, inflammation and Immunity. RUNMC, Nijmegen, The Netherlands
⨯

Systemic Inflammation Decreases Pain Threshold in Humans In Vivo

Moniek de Goeij,
Lucas T. van Eijk,
Pascal Vanelderen,
Oliver H. Wilder-Smith,
Kris C. Vissers,
Johannes G. van der Hoeven,
Matthijs Kox,
Gert Jan Scheffer,
Peter Pickkers

Published: December 17, 2013
https://doi.org/10.1371/journal.pone.0084159

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Pain
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Endotoxins
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Inflammation
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Pain sensation
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Sensory perception
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Hyperalgesia
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