Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

• Stephen Antonysamy,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Bradley Condon,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Zhanna Druzina,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Jeffrey B. Bonanno,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine University, Jack and Pearl Resnik Campus, Bronx, New York, United States of America

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• Tarun Gheyi,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Feiyu Zhang,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Iain MacEwan,

  Affiliation Department of Radiology, Loma Linda University Medical Center, Loma Linda, California, United States of America

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• Aiping Zhang,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Sheela Ashok,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Logan Rodgers,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• Marijane Russell,

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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• John Gately Luz

  * E-mail: luz_john@lilly.com

  Affiliation Lilly Biotechnology Center San Diego, San Diego, California, United States of America

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