A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages

Yisett González; Deborah Doens; Ricardo Santamaría; Marla Ramos; Carlos M. Restrepo; Luciana Barros de Arruda; Ricardo Lleonart; Marcelino Gutiérrez; Patricia L. Fernández

doi:10.1371/journal.pone.0084107

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Peer-reviewed

Research Article

A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages

Yisett González,

Affiliations Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá, Department of Biotechnology, Acharya Nagarjuna University, Guntur, India
⨯
Deborah Doens,

Affiliations Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá, Department of Biotechnology, Acharya Nagarjuna University, Guntur, India
⨯
Ricardo Santamaría,

Affiliation Centro de Descubrimiento de Drogas y Biodiversidad, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá
⨯
Marla Ramos,

Affiliation Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá
⨯
Carlos M. Restrepo,

Affiliations Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá, Department of Biotechnology, Acharya Nagarjuna University, Guntur, India
⨯
Luciana Barros de Arruda,

Affiliation Laboratorio de Genética e Imunologia das Infecções Virais, Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Ricardo Lleonart,

Affiliation Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá
⨯
Marcelino Gutiérrez,

Affiliation Centro de Descubrimiento de Drogas y Biodiversidad, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá
⨯
Patricia L. Fernández

* E-mail: pllanes@indicasat.org.pa

Affiliation Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá
⨯

A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages

Yisett González,
Deborah Doens,
Ricardo Santamaría,
Marla Ramos,
Carlos M. Restrepo,
Luciana Barros de Arruda,
Ricardo Lleonart,
Marcelino Gutiérrez,
Patricia L. Fernández

Published: December 16, 2013
https://doi.org/10.1371/journal.pone.0084107

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