Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H. M. Kilgour; Iain J. Gallagher; Alasdair M. J. MacLullich; Ruth Andrew; Calum D. Gray; Philippa Hyde; Henning Wackerhage; Holger Husi; James A. Ross; John M. Starr; Karen E. Chapman; Kenneth C. H. Fearon; Brian R. Walker; Carolyn A. Greig

doi:10.1371/journal.pone.0084057

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Peer-reviewed

Research Article

Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H. M. Kilgour ,

* E-mail: a.kilgour@ed.ac.uk

Affiliation Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, United Kingdom
⨯
Iain J. Gallagher,

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Alasdair M. J. MacLullich,

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, United Kingdom, Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Ruth Andrew,

Affiliation Endocrinology Unit, Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Calum D. Gray,

Affiliation Clinical Research Imaging Centre, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Philippa Hyde,

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Henning Wackerhage,

Affiliation School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Holger Husi,

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
James A. Ross,

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
John M. Starr,

Affiliation Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, United Kingdom
⨯
Karen E. Chapman,

Affiliation Endocrinology Unit, Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Kenneth C. H. Fearon,

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Brian R. Walker,

Affiliation Endocrinology Unit, Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Carolyn A. Greig

Affiliation Department of Clinical and Surgical Sciences, Division of Health Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯

Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H. M. Kilgour,
Iain J. Gallagher,
Alasdair M. J. MacLullich,
Ruth Andrew,
Calum D. Gray,
Philippa Hyde,
Henning Wackerhage,
Holger Husi,
James A. Ross,
John M. Starr

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0084057

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